Endocrine Abstracts

Introduction: Hypoglycemia is a rare clinical problem in patients not being treated for diabetes mellitus and requires further evaluation and management if Whipple’s triad is present. Insulinoma commonly presents with fasting hypoglycemia. Insulinoma is rarely associated with type 1 multiple endocrine neoplasia, when tumors are usually multiple and more frequently malignant. The diagnosis of insulinoma is established by demonstrating inappropriately high serum insulin con...

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...